intranasal oncolytic virotherapy with cxcr4-enhanced stem cells extends survival in mouse model of glioma
Clicks: 174
ID: 251452
2016
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
30.0
/100
174 views
32 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #74 of 101 articles by views in nature reviews gastroenterology & hepatology
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
The challenges to effective drug delivery to brain tumors are twofold: (1) there is a lack of non-invasive methods of local delivery and (2) the blood-brain barrier limits systemic delivery. Intranasal delivery of therapeutics to the brain overcomes both challenges. In mouse model of malignant glioma, we observed that a small fraction of intranasally delivered neural stem cells (NSCs) can migrate to the brain tumor site. Here, we demonstrate that hypoxic preconditioning or overexpression of CXCR4 significantly enhances the tumor-targeting ability of NSCs, but without altering their phenotype only in genetically modified NSCs. Modified NSCs deliver oncolytic virus to glioma more efficiently and extend survival of experimental animals in the context of radiotherapy. Our findings indicate that intranasal delivery of stem cell-based therapeutics could be optimized for future clinical applications, and allow for safe and repeated administration of biological therapies to brain tumors and other CNS disorders.
| Reference Key |
dey2016stemintranasal
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Mahua Dey;Dou Yu;Deepak Kanojia;Gina Li;Madina Sukhanova;Drew A. Spencer;Katatzyna C. Pituch;Lingjiao Zhang;Yu Han;Atique U. Ahmed;Karen S. Aboody;Maciej S. Lesniak;Irina V. Balyasnikova |
| Journal | nature reviews gastroenterology & hepatology |
| Year | 2016 |
| DOI |
10.1016/j.stemcr.2016.07.024
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.