association between hla-e gene polymorphism and unexplained recurrent spontaneous abortion (rsa) in iranian women

Klicks: 212
ID: 251442
2016
Kostenloses PDF
Artikelqualität & Leistungskennzahlen
Gesamtqualität
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
KI-Qualitätsbewertung
Nicht analysiert
Readership in this journal
Steady

Ranked #35 of 51 articles by views in isprs international journal of geo-information

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Background: Human leukocyte antigen-E (HLA-E)is a non-classical major histocompatibility complex (MHC) class I antigens which expressed on extra villous cytotrophoblast, which interacts with NKG2A, is an inhibitory receptor on natural killer (NK) cells and leading to down regulation of immune response in the maternal-fetal interface and provides maternal immune tolerance of the fetus. Objective: This study was designated to investigate the gene frequencies of E0101 and E0103 in HLA-E gene in Iranian women with recurrent spontaneous abortion (RSA). Materials and Methods: Amplification Refractory Mutation System (ARMS-PCR) technique was carried out to detect polymorphism in exon 3 of the HLA-E gene in women with RSA and controls (n=200). Differences between groups were analyzed by SPSS19 software using χ2 test. Results: There was no significant difference in the allele frequencies of the HLA-E polymorphism between RSA and fertile controls but HLA-E 0101/0103 heterozygous genotype was found to be significantly higher in RSA group (p=0.006, OR=1.73), so this genotype might confer susceptibility to RSA. Conclusion: Our results suggest that HLA-E 0101/0103 heterozygous genotype leads to increase of RSA risk. It seems that by genotyping of HLA-E polymorphism, we can predict the risk of RSA in infertile women
Referenzschlüssel
fotoohi2016iranianassociation Verwenden Sie diesen Schlüssel zum automatischen Zitieren im Manuskript bei Verwendung von SciMatic Manuscript Manager oder Thesis Manager
Autoren ;Maryam Fotoohi;Nasrin Ghasemi;Seyed Ali Mirghanizadeh;Mahmood Vakili;Morteza Samadi
Zeitschrift isprs international journal of geo-information
Jahr 2016
DOI
DOI nicht gefunden
URL
http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/2018/pdf
Schlüsselwörter
gynecology and obstetricsreproduction

Zitationen

Keine Zitationen gefunden. Um eine Zitation hinzuzufügen, kontaktieren Sie den Administrator unter info@scimatic.org

Kommentare

Noch keine Kommentare. Seien Sie der Erste, der diesen Artikel kommentiert.