synthesis and evaluation of 2,4-disubstituted quinazoline derivatives with potent anti-angiogenesis activities
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2014
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Abstract
A series of 2,4-disubstituted quinazoline derivatives were designed and synthesized. The biological results showed that most of quinazoline derivatives exhibited potent antiproliferative activities against a panel of three tumor cell lines and a good inhibitory effect against the adhesion and migration of human umbilical vein endothelial cells (HUVECs). Among these compounds, 11d was the most potent agent, that also exhibited the highest anti-angiogenesis activities in the chick embryo chorioallantoic membrane (CAM) assay.
| Reference Key |
yu2014moleculessynthesis
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|---|---|
| Authors | ;Guangjin Yu;Zeng Li;Liang Tang;Qiru Xiong |
| Journal | Journal of ethnopharmacology |
| Year | 2014 |
| DOI |
10.3390/molecules19078916
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| URL | |
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