synthesis and evaluation of 2,4-disubstituted quinazoline derivatives with potent anti-angiogenesis activities

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ID: 251381
2014
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Аннотация
A series of 2,4-disubstituted quinazoline derivatives were designed and synthesized. The biological results showed that most of quinazoline derivatives exhibited potent antiproliferative activities against a panel of three tumor cell lines and a good inhibitory effect against the adhesion and migration of human umbilical vein endothelial cells (HUVECs). Among these compounds, 11d was the most potent agent, that also exhibited the highest anti-angiogenesis activities in the chick embryo chorioallantoic membrane (CAM) assay.
Ссылочный ключ
yu2014moleculessynthesis Используйте этот ключ для автоцитирования в рукописи при использовании SciMatic Manuscript Manager или Thesis Manager
Авторы ;Guangjin Yu;Zeng Li;Liang Tang;Qiru Xiong
Журнал Journal of ethnopharmacology
Год 2014
DOI
10.3390/molecules19078916
URL
http://www.mdpi.com/1420-3049/19/7/8916
Ключевые слова
synthesis 2 nickel cross-coupling coordination chemistry paramagnetic complexesorganic chemistry

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