exploring compound promiscuity patterns and multi-target activity spaces
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ID: 250730
2014
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Abstract
Compound promiscuity is rationalized as the specific interaction of a small molecule with multiple biological targets (as opposed to non-specific binding events) and represents the molecular basis of polypharmacology, an emerging theme in drug discovery and chemical biology. This concise review focuses on recent studies that have provided a detailed picture of the degree of promiscuity among different categories of small molecules. In addition, an exemplary computational approach is discussed that is designed to navigate multi-target activity spaces populated with various compounds.
| Reference Key |
hu2014computationalexploring
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|---|---|
| Authors | ;Ye Hu;Disha Gupta-Ostermann;Jürgen Bajorath |
| Journal | ceramics international |
| Year | 2014 |
| DOI |
10.5936/csbj.201401003
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| URL | |
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