surface-based regional homogeneity in first-episode, drug-naïve major depression: a resting-state fmri study
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ID: 250558
2014
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Abstract
Background. Previous volume-based regional homogeneity (ReHo) studies neglected the intersubject variability in cortical folding patterns.
Recently, surface-based ReHo was developed to
reduce the intersubject variability and to increase statistical power. The present study used this novel surface-based ReHo
approach to explore the brain functional activity differences between first-episode, drug-naïve MDD patients and healthy controls. Methods. Thirty-three first-episode, drug-naïve MDD patients and 32 healthy controls participated in structural and resting-state fMRI scans. MDD patients were rated with a 17-item Hamilton Rating Scale for Depression prior to the scan. Results. In comparison with the healthy controls, MDD patients showed reduced surface-based ReHo in the left insula. There was no increase in surface-based ReHo in MDD patients. The surface-based ReHo value in the left insula was not significantly correlated with the clinical information or the depressive scores in the MDD group. Conclusions. The decreased surface-based ReHo in the left insula in MDD may lead to the abnormal top-down cortical-limbic regulation of emotional and cognitive information. The surface-based ReHo may be a useful index to explore the pathophysiological mechanism of MDD.
| Reference Key |
li2014biomedsurface-based
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| Authors | ;Hui-Jie Li;Xiao-Hua Cao;Xing-Ting Zhu;Ai-Xia Zhang;Xiao-Hui Hou;Yong Xu;Xi-Nian Zuo;Ke-Rang Zhang |
| Journal | spectrochimica acta - part a: molecular and biomolecular spectroscopy |
| Year | 2014 |
| DOI |
10.1155/2014/374828
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| URL | |
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