investigation of genotoxic potential of various sizes fe2o3 nanoparticles with comet assay
Clicks: 220
ID: 250454
2015
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
30.0
/100
220 views
38 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #210 of 264 articles by views in chemical record (new york, ny)
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 264 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Nanoparticles are found very common in nature. For instance, proteins exist in almost all biological systems and metal-oxide nanoparticles are easily produced etc. Iron oxide nanoparticles with unique magnetic properties have a high potential to use in several biomedical, bioengineering and in vivo applications, including tissue repair, magnetic resonance imaging, immunoassay, drug delivery, detoxification of biologic fluids, cell sorting, and hyperthermia. Although various surface modifications are being done for making these nonbiodegradable nanoparticles more biocompatible . But their toxic potential is still a major concern. Therefore, it is necessary to use further examination assay systems in order to check nanoparticle effects.
In this study, genotoxic potential of <50 nm and <100 nm Fe2O3 nanoparticles were investigated by using Comet Assay. Allium cepa root meristems were exposed with five doses (0.001, 0.01, 0.1, 1, 10 mM) of <50 nm for 4 hour and three doses (2.5, 5 (EC50), 10 mM) for <100 nm of Fe2O3 nanoparticle for 24 and 96 h. Methyl methanesulfonate -MMS (10 ppm) was used as a positive control. The results were also analyzed statistically by using SPSS by Windows, 18.0. It was determined that different doses of <50 nm Fe2O3 nanoparticle have no genotoxic effect of DNA. Different doses of <100 nm Fe2O3 have no genotoxic but only 10 mM dose have genotoxic effect on DNA. When compared <50 nm with <100 nm of Fe2O3 nanoparticle; <50 nm have more effects than <100 nm of Fe2O3 on DNA damage.
Abstract Quality Issue:
This abstract appears to be incomplete or contains metadata (106 words).
Try re-searching for a better abstract.
| Reference Key |
cierci2015frontiersinvestigation
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;İbrahim Hakkı Ciğerci |
| Journal | chemical record (new york, ny) |
| Year | 2015 |
| DOI |
10.3389/conf.fgene.2015.01.00017
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.