treadmill training increases sirt-1 and pgc-1α protein levels and ampk phosphorylation in quadriceps of middle-aged rats in an intensity-dependent manner
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ID: 250256
2014
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Abstract
The present study investigated the effects of running at 0.8 or 1.2 km/h on inflammatory proteins (i.e., protein levels of TNF-α, IL-1β, and NF-κB) and metabolic proteins (i.e., protein levels of SIRT-1 and PGC-1α, and AMPK phosphorylation) in quadriceps of rats. Male Wistar rats at 3 (young) and 18 months (middle-aged rats) of age were divided into nonexercised (NE) and exercised at 0.8 or 1.2 km/h. The rats were trained on treadmill, 50 min per day, 5 days per week, during 8 weeks. Forty-eight hours after the last training session, muscles were removed, homogenized, and analyzed using biochemical and western blot techniques. Our results showed that: (a) running at 0.8 km/h decreased the inflammatory proteins and increased the metabolic proteins compared with NE rats; (b) these responses were lower for the inflammatory proteins and higher for the metabolic proteins in young rats compared with middle-aged rats; (c) running at 1.2 km/h decreased the inflammatory proteins and increased the metabolic proteins compared with 0.8 km/h; (d) these responses were similar between young and middle-aged rats when trained at 1.2 km. In summary, the age-related increases in inflammatory proteins, and the age-related declines in metabolic proteins can be reversed and largely improved by treadmill training.
| Reference Key |
oliveira2014mediatorstreadmill
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|---|---|
| Authors | ;Nara R. C. Oliveira;Scherolin O. Marques;Thais F. Luciano;José R. Pauli;Leandro P. Moura;Erico Caperuto;Bruno L. S. Pieri;Julia Engelmann;Gisele Scaini;Emilio L. Streck;Fabio S. Lira;Ricardo A. Pinho;Eduardo R. Ropelle;Adelino S. R. Silva;Cláudio T. De Souza |
| Journal | polyhedron |
| Year | 2014 |
| DOI |
10.1155/2014/987017
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| URL | |
| Keywords |
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