anti-inflammatory and anti-arthritic activities of merremia tridentate (l.) hall. f.
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ID: 250158
2009
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Abstract
The various extracts of Merremia tridentate were investigated for its anti-inflammatory and anti-arthritic activities in male albino rats. The anti-inflammatory activity was carried out using carrageenan-induced rat paw oedema model and the anti-arthritic activity was carried out using complete Freund’s adjuvant induced arthritis model. Indomethacin (10 mg/kg bw) was used as a standard drug. The ethanol extract of M. tridentate exhibited significant dose dependent activity in acute inflammation and the doses of 100 mg/kg bw and 200 mg/kg bw produced 38.3% and 42.8% inhibition respectively after 3 h as compared with that of the standard drug which showed 48.5% inhibition. In arthritis model, the doses of 100 mg/kg bw and 200 mg/kg bw of the ethanol extract produced 49.0% and 51.7% inhibition respectively after 19 days when compared with that of the standard drug (55.5%). Both doses of the ethanol extract of M. tridentate exhibit significant anti-inflammatory and anti-arthritic activities.
| Reference Key |
kamalutheen2009e-journalanti-inflammatory
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|---|---|
| Authors | ;M. Kamalutheen;S. Gopalakrishnan;T. Syed Ismail |
| Journal | Journal of pharmaceutical and biomedical analysis |
| Year | 2009 |
| DOI |
10.1155/2009/670617
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| URL | |
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