preparation and characterization of a gastric floating dosage form of capecitabine
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2013
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Abstract
Gastrointestinal disturbances, such as nausea and vomiting,
are considered amongst the main adverse effects associated with
oral anticancer drugs due to their fast release in the gastrointestinal tract (GIT).
Sustained release formulations with proper release profiles can overcome some side
effects of conventional formulations. The current study was designed to prepare
sustained release tablets of Capecitabine, which is approved by the Food and Drug
Administration (FDA) for the treatment of advanced breast cancer, using hydroxypropyl
methylcellulose (HPMC), carbomer934P, sodium alginate, and sodium bicarbonate.
Tablets were prepared using the wet granulation method and characterized such that
floating lag time, total floating time, hardness, friability, drug content, weight uniformity,
and in vitro drug release were investigated. The sustained release tablets
showed good hardness and passed the friability test. The tablets’ floating lag
time was determined to be 30–200 seconds, and it floated more
than 24 hours and released the drug for 24 hours. Then, the stability test was done and
compared with the initial samples. In conclusion, by adjusting the right ratios of the excipients
including release-retarding gel-forming polymers like HPMC K4M,
Na alginate, carbomer934P, and sodium bicarbonate, sustained release Capecitabine floating tablet was formulated.
| Reference Key |
davoudi2013biomedpreparation
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|---|---|
| Authors | ;Ehsan Taghizadeh Davoudi;Mohamed Ibrahim Noordin;Ali Kadivar;Behnam Kamalidehghan;Abdoreza Soleimani Farjam;Hamid Akbari Javar |
| Journal | spectrochimica acta - part a: molecular and biomolecular spectroscopy |
| Year | 2013 |
| DOI |
10.1155/2013/495319
|
| URL | |
| Keywords |
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