complete psa remission without adjuvant therapy after secondary lymph node surgery in selected patients with biochemical relapse after radical prostatectomy and pelvic lymph node dissection
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ID: 249488
2012
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Abstract
Introduction. To evaluate whether secondary resection of lymph node (LN) metastases (LNMs) can result in PSA remission, we analysed the PSA outcome after resection of LNM detected on PET/CT in patients with biochemical failure. Materials and Methods. 11 patients with PSA relapse (mean 3.02 ng/mL, range 0.5–9.55 ng/mL) after radical prostatectomy without adjuvant therapy were included. Suspicious LN (1–3) detected on choline PET/CT and nearby LN were openly dissected (09/04–02/11). The PSA development was examined. Histological and PET/CT findings were compared. Results. 9 of 10 patients with histologically confirmed LNM showed a PSA response. 4 of 9 patients with single LNM had a complete permanent PSA remission (mean followup 31.8, range 1–48 months). Of metastasis-suspicious LNs (14) 12 could be histologically confirmed. The additionally removed 25 LNs were all correctly negative. Conclusions. The complete PSA remissions after secondary resection of single LNM argue for a feasible therapeutic benefit without adjuvant therapy. For this purpose the choline PET/CT is in spite of its limitations currently the most reliable routinely available diagnostic tool.
| Reference Key |
winter2012advancescomplete
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| Authors | ;Alexander Winter;Jens Uphoff;Rolf-Peter Henke;Friedhelm Wawroschek |
| Journal | electronic journal of biotechnology |
| Year | 2012 |
| DOI |
10.1155/2012/609612
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| URL | |
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