circulating monoclonal igg1-kappa antibodies causing anti-glomerular basement membrane nephritis
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2017
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Abstract
Anti-glomerular basement membrane (GBM) antibody disease is a rare but well-characterized cause of glomerulonephritis. Patients present with rapidly progressive renal failure with hemoptysis. Early diagnosis is crucial in salvaging the renal damage and life-threatening pulmonary hemorrhage. Plasmapheresis and immunosuppression is the mode of therapy. Anti-GBM antibodies are polyclonal in nature. However, rare monoclonal antibodies can cause similar destruction of glomerular capillary walls. We describe distinct combination of circulating monoclonal and anti-GBM nephritis.
| Reference Key |
vankalakunti2017indiancirculating
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|---|---|
| Authors | ;M Vankalakunti;R Nada;A Kumar;K Patro;S Ramakrishnan;D Rangarajan |
| Journal | journal of the chemical society - perkin transactions 1 |
| Year | 2017 |
| DOI |
10.4103/ijn.IJN_113_16
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| URL | |
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