significant roles played by interleukin-10 in outcome of pregnancy

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ID: 249201
2016
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Abstract
Imbalanced immune responses against fetus alloantigens can lead to abnormality in pregnancy. Interleukin-10(IL-10) plays key roles in regulation of immune responses against self and foreign antigens to induce tolerance to these antigens. Therefore, alteration in expression of IL-10 during pregnancy may result in several pathologic conditions such as preterm labor. IL-10 leads to a normal pregnancy via several molecular mechanisms including development of tolerogenic dendritic cells, T regulatory lymphocytes and activation of the JAK1/STAT3 pathway in the target cells. This review has collected recent data regarding the status of IL-10 expression during term and preterm deliveries and also its molecular mechanisms that lead to a normal pregnancy.
Reference Key
mobini2016iraniansignificant Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Masoud Mobini;Maryam Mortazavi;Somayeh Nadi;Mohammad Zare-Bidaki;Somayeh Pourtalebi;Mohammad Kazemi Arababadi
Journal PloS one
Year 2016
DOI
DOI not found
URL
http://ijbms.mums.ac.ir/article_6530_92c70d6e5b9ce0c1032c074d182dcede.pdf
Keywords
preterm delivery il-10

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