seroprevalence of chronic hepatitis b, as determined from dried blood spots, among children and their mothers in central lao people's democratic republic: a multistage, stratified cluster sampling survey

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ID: 249084
2015
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Abstract
Background: There is limited information regarding the prevalence of hepatitis B in Lao PDR, where the hepatitis disease burden is substantial. Thus, reliable seroprevalence data is needed for the disease, based on probability sampling. Methods: A stratified, multistage, cluster sampling survey of hepatitis B surface antigen (HBsAg) positivity among children aged 5–9 years and their mothers aged 15–45 years was conducted. Participants were selected randomly from the central region of Lao PDR via probability-proportional-to-size sampling. Blood samples were collected onto filter paper and subsequently analyzed using a chemiluminescent microparticle immunoassay. Results: A total of 911 mother-and-child pairs were collected; the seroprevalence of HBsAg was estimated to be 2.1% (95% confidence interval 0.8–3.4%) among children and 4.1% (95% confidence interval 2.6–5.5%) in their mothers after taking into account the sampling design and the weight of each sample. The children's HBsAg positivity was positively associated with maternal infection and being born in a non-health facility, while the maternal infection status was not associated with any background characteristic. Conclusions: Lao PDR has a relatively lower HBsAg prevalence in the general population compared to surrounding countries. To ensure comparability to other countries and to future data, rapid field tests are recommended for a nationwide prevalence survey.
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komada2015internationalseroprevalence Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
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Journal israel journal of chemistry
Year 2015
DOI
10.1016/j.ijid.2015.04.020
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