a case of refractory type iii hyperlypoproteinemia successfully treated with plasmapheresis
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ID: 249036
2004
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Abstract
A 42-year-old male was hospitalized in Department of Endocrinologyfor evaluation of persistent hypertriglyceridemia and hypercholestrolemia.He was normal on physical examination except having multiple xanthomasin elbow, knee and ankle. ApoE genotyping was performed by PCR andapoE phenotype was found to be E2/E2. Firstly, he was treated withatorvastatin (40mg/day) and niacin (1500mg/day) but it was found that thepatient did not respond the after three months of the treatment. Then he wastreated with plasmapheresis twice a week. After three weeks ofplasmapheresis treatment triglyceride and cholesterol levels was markedlydecreased.Plasmapheresis can be highly effective in removing the lipoproteinremnantparticles, leading to generalized improvement in the lipoproteinprofile in severe type III hyperlipidemia, which do not respond conventionalthreapies as in our case.
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| Authors | ;Alpaslan Tuzcu;Mithat Bahceci;Deniz Gökalp;Orhan Ayyıldiz;Yekta Tüzün |
| Journal | journal of sulfur chemistry |
| Year | 2004 |
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