The H3 histone chaperone NASP escorts CenH3 in Arabidopsis.

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ID: 24851
2019
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Ranked #20 of 29 articles by views in The Plant journal : for cell and molecular biology

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Abstract
Centromeres define the chromosomal position where kinetochores form to link the chromosome to microtubules during mitosis and meiosis. Centromere identity is determined by incorporation of a specific histone H3 variant termed CenH3. As for other histones, escort and deposition of CenH3 must be ensured by histone chaperones, which handle the non-nucleosomal CenH3 pool and replenish CenH3 chromatin in dividing cells. Here, we show that the Arabidopsis orthologue of the mammalian NUCLEAR AUTOANTIGENIC SPERM PROTEIN (NASP) and S. pombe histone chaperone Sim3 is a soluble nuclear protein that binds the histone variant CenH3 and affects its abundance at the centromeres. NASP is co-expressed with Arabidopsis CenH3 in dividing cells and binds directly to both the N-terminal tail and the histone fold domain of non-nucleosomal CenH3. Reduced NASP expression negatively affects CenH3 deposition, identifying NASP as a CenH3 histone chaperone. This article is protected by copyright. All rights reserved.
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Authors Le Goff, Samuel;Nur Keçeli, Burcu;Jerabkova, Hana;Heckmann, Stefan;Rutten, Twan;Cotterell, Sylviane;Schubert, Veit;Roitinger, Elisabeth;Mechtler, Karl;Franklin, F Christopher H;Tatout, Christophe;Houben, Andreas;Geelen, Danny;Probst, Aline V;Lermontova, Inna;
Journal The Plant journal : for cell and molecular biology
Year 2019
DOI
10.1111/tpj.14518
URL
Keywords Keywords not found

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