isolation and assessment of the in vitro anti-tumor activity of smenothiazole a and b, chlorinated thiazole-containing peptide/polyketides from the caribbean sponge, smenospongia aurea
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2015
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Abstract
The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A (3) and B (4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over ovarian cancer cells and a pro-apoptotic mechanism.
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esposito2015marineisolation
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| Authors | ;Germana Esposito;Roberta Teta;Roberta Miceli;Luca S. Ceccarelli;Gerardo Della Sala;Rosa Camerlingo;Elena Irollo;Alfonso Mangoni;Giuseppe Pirozzi;Valeria Costantino |
| Journal | jixie gongcheng xuebao/journal of mechanical engineering |
| Year | 2015 |
| DOI |
10.3390/md13010444
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