isolation and assessment of the in vitro anti-tumor activity of smenothiazole a and b, chlorinated thiazole-containing peptide/polyketides from the caribbean sponge, smenospongia aurea

Clicks: 297
ID: 248361
2015
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #55 of 194 articles by views in jixie gongcheng xuebao/journal of mechanical engineering

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 194 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A (3) and B (4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over ovarian cancer cells and a pro-apoptotic mechanism.
Reference Key
esposito2015marineisolation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Germana Esposito;Roberta Teta;Roberta Miceli;Luca S. Ceccarelli;Gerardo Della Sala;Rosa Camerlingo;Elena Irollo;Alfonso Mangoni;Giuseppe Pirozzi;Valeria Costantino
Journal jixie gongcheng xuebao/journal of mechanical engineering
Year 2015
DOI
10.3390/md13010444
URL
http://www.mdpi.com/1660-3397/13/1/444
Keywords
apoptosis thiazole structure elucidation marine natural products mtt assaysbiology (general)

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.