tombu and combu as novel uronium-type peptide coupling reagents derived from oxyma-b
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ID: 248273
2014
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Abstract
Here we describe two novel uronium salts, TOMBU and COMBU, derived from the recently described Oxyma-B for use in peptide bond synthesis. These coupling reagents are more stable than COMU in DMF. Furthermore, using various peptide synthetic models in solution and solid-phase synthesis, we reveal that they show better performance than HBTU in terms of preserving chiral integrity and coupling yields, but slightly worse performance than COMU.
| Reference Key |
jad2014moleculestombu
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|---|---|
| Authors | ;Yahya E. Jad;Sherine N. Khattab;Beatriz G. de la Torre;Thavendran Govender;Hendrik G. Kruger;Ayman El-Faham;Fernando Albericio |
| Journal | Journal of ethnopharmacology |
| Year | 2014 |
| DOI |
10.3390/molecules191118953
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| URL | |
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