distinctive mesenchymal-parenchymal cell pairings govern b cell differentiation in the bone marrow
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ID: 247566
2016
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Abstract
Bone marrow niches for hematopoietic progenitor cells are not well defined despite their critical role in blood homeostasis. We previously found that cells expressing osteocalcin, a marker of mature osteolineage cells, regulate the production of thymic-seeding T lymphoid progenitors. Here, using a selective cell deletion strategy, we demonstrate that a subset of mesenchymal cells expressing osterix, a marker of bone precursors in the adult, serve to regulate the maturation of early B lymphoid precursors by promoting pro-B to pre-B cell transition through insulin-like growth factor 1 (IGF-1) production. Loss of Osx+ cells or Osx-specific deletion of IGF-1 led to a failure of B cell maturation and the impaired adaptive immune response. These data highlight the notion that bone marrow is a composite of specialized niches formed by pairings of specific mesenchymal cells with parenchymal stem or lineage committed progenitor cells, thereby providing distinctive functional units to regulate hematopoiesis.
| Reference Key |
yu2016stemdistinctive
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|---|---|
| Authors | ;Vionnie W.C. Yu;Stefania Lymperi;Toshihiko Oki;Alexandra Jones;Peter Swiatek;Radovan Vasic;Francesca Ferraro;David T. Scadden |
| Journal | nature reviews gastroenterology & hepatology |
| Year | 2016 |
| DOI |
10.1016/j.stemcr.2016.06.009
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