fosfolipasas a2 y su importancia clínica

Clicks: 94
ID: 247496
2002
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Ranked #150 of 320 articles by views in european journal of cancer prevention : the official journal of the european cancer prevention organisation (ecp)

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Abstract
We review our current knowledge of the molecular and biochemical characteristics of phospholipases A2 (PLA2) enzymes. PLA2 are a superfamily group of enzymes that hydrolyze membrane Iipids to produce arachidonic acid and other precursors of prostaglandins. PLA2 are enzymes involved in inflammatory process, remodeling cell membrane and in intracellular signaling. We also describe the pathological process where PLA2 is involved. We describe the specific inhibitor for each group of  PLA2 enzymes. Besides, the possible and real clinical applications of each inhibitor is analyzed. The therapeutic field of  intervention is wide and inhibition recently developed allows specific inhibition of each group of  PLA2. New treatments based on specific inhibition of a particular group of  PLA2 enzymes are awaited for diseases as diabetes, sepsis autoimmune diseases and infectious diseases.
Reference Key
buitrago2002revistafosfolipasas Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Rafael Buitrago;Jorge Enrique Gómez Marín
Journal european journal of cancer prevention : the official journal of the european cancer prevention organisation (ecp)
Year 2002
DOI
DOI not found
URL
https://revistas.unal.edu.co/index.php/revfacmed/article/view/19861
Keywords
sepsis inflamaciónmedicinemedicine (general)

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