aging and synaptic plasticity: a review
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ID: 247487
2002
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Abstract
Aging affects all systems, but the brain seems
to be particularly vulnerable to the action of
negative, age-dependent factors. A gradual loss
of memory functions is one of the earliest and
most widespread consequences of brain aging.
The causes for such impairment are still unclear.
Long-term potentiation (LTP) is one form of
neural plasticity, which has been proposed as the
cellular correlate for memory. LTP is affected by
aging, and such alteration might be causally
related to memory dysfunction. In the present
paper, we review the evidence sustaining the
existence of a causal link between cognitive and
LTP impairments, as well as the possible
mechanisms involved. New results indicate a
possible involvement of a deficient reinforcement
of LTP by affective influences.
| Reference Key |
bergado2002neuralaging
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|---|---|
| Authors | ;Jorge A. Bergado;William Almaguer |
| Journal | tetrahedron |
| Year | 2002 |
| DOI |
10.1155/NP.2002.217
|
| URL | |
| Keywords |
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