structurally related monoterpenes p-cymene, carvacrol and thymol isolated from essential oil from leaves of lippia sidoides cham. (verbenaceae) protect mice against elastase-induced emphysema

Clicks: 772
ID: 246829
2016
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Article Quality & Performance Metrics
Overall Quality High Overall Quality
80.1 /100
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AI Quality Assessment 🥈 High Quality
80.7 /100
Academic Rigor 88.0%
Novelty 70.0%
Clarity 85.0%
Key Strengths
  • Well-defined research question
  • Robust methodology using animal model
  • Clear presentation of results
Areas for Improvement
  • Limited generalizability to humans from animal model
  • Lack of mechanistic depth beyond inflammation markers
  • Focus on a specific type of emphysema (elastase-induced)
AI Recommendations

Future studies should focus on elucidating the specific molecular mechanisms of action of these monoterpenes. Clinical trials are needed to confirm the efficacy and safety of these compounds in humans. Consider exploring the potential synergistic effects of combining these monoterpenes with existing COPD treatments.

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Abstract
Background: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction and inflammation. Natural products, such as monoterpenes, displayed anti-inflammatory and anti-oxidant activities and can be used as a source of new compounds to COPD treatment. Our aim was to evaluate, in an elastase-induced pulmonary emphysema in mice, the effects of and underlying mechanisms of three related natural monoterpenes (p-cymene, carvacrol and thymol) isolated from essential oil from leaves Lippia sidoides Cham. (Verbenaceae). Methods: Mices received porcine pancreatic elastase (PPE) and were treated with p-cymene, carvacrol, thymol or vehicle 30 min later and again on 7th, 14th and 28th days. Lung inflammatory profile and histological sections were evaluated. Results: In the elastase-instilled animals, the tested monoterpenes reduced alveolar enlargement, macrophages and the levels of IL-1β, IL-6, IL-8 and IL-17 in bronchoalveolar lavage fluid (BALF), and collagen fibers, MMP-9 and p-65-NF-κB-positive cells in lung parenchyma (p < 0.05). All treatments attenuated levels of 8-iso-PGF2α but only thymol was able to reduced exhaled nitric oxide (p < 0.05). Conclusion: Monoterpenes p-cymene, carvacrol and thymol reduced lung emphysema and inflammation in mice. No significant differences among the three monoterpenes treatments were found, suggesting that the presence of hydroxyl group in the molecular structure of thymol and carvacrol do not play a central role in the anti-inflammatory effects.
Reference Key
games2016moleculesstructurally Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ellen Games;Marina Guerreiro;Fernanda R. Santana;Nathalia M. Pinheiro;Emerson A. de Oliveira;Fernanda D.T.Q.S. Lopes;Clarice R. Olivo;Iolanda F.L.C. Tibério;Mílton A. Martins;João Henrique G. Lago;Carla M. Prado
Journal Journal of ethnopharmacology
Year 2016
DOI
10.3390/molecules21101390
URL
http://www.mdpi.com/1420-3049/21/10/1390
Keywords
copd thymol carvacrol monoterpenes

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