structurally related monoterpenes p-cymene, carvacrol and thymol isolated from essential oil from leaves of lippia sidoides cham. (verbenaceae) protect mice against elastase-induced emphysema
Clicks: 745
ID: 246829
2016
Article Quality & Performance Metrics
Overall Quality
High Overall Quality
80.1
/100
Combines engagement data with AI-assessed academic quality
Reader Engagement
Steady Performance
74.5
/100
745 views
512 readers
Trending
AI Quality Assessment
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High Quality
80.7
/100
Academic Rigor
88.0%
Novelty
70.0%
Clarity
85.0%
Key Strengths
- Well-defined research question
- Robust methodology using animal model
- Clear presentation of results
Areas for Improvement
- Limited generalizability to humans from animal model
- Lack of mechanistic depth beyond inflammation markers
- Focus on a specific type of emphysema (elastase-induced)
AI Recommendations
Future studies should focus on elucidating the specific molecular mechanisms of action of these monoterpenes. Clinical trials are needed to confirm the efficacy and safety of these compounds in humans. Consider exploring the potential synergistic effects of combining these monoterpenes with existing COPD treatments.
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2025 Relevance
Relevance
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80%
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11
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65%
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92%
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72%
Interdisciplinary Value
🔀 Cross-disciplinary
60%
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Real-world Applications
75%
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Abstract
Background: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction and inflammation. Natural products, such as monoterpenes, displayed anti-inflammatory and anti-oxidant activities and can be used as a source of new compounds to COPD treatment. Our aim was to evaluate, in an elastase-induced pulmonary emphysema in mice, the effects of and underlying mechanisms of three related natural monoterpenes (p-cymene, carvacrol and thymol) isolated from essential oil from leaves Lippia sidoides Cham. (Verbenaceae). Methods: Mices received porcine pancreatic elastase (PPE) and were treated with p-cymene, carvacrol, thymol or vehicle 30 min later and again on 7th, 14th and 28th days. Lung inflammatory profile and histological sections were evaluated. Results: In the elastase-instilled animals, the tested monoterpenes reduced alveolar enlargement, macrophages and the levels of IL-1β, IL-6, IL-8 and IL-17 in bronchoalveolar lavage fluid (BALF), and collagen fibers, MMP-9 and p-65-NF-κB-positive cells in lung parenchyma (p < 0.05). All treatments attenuated levels of 8-iso-PGF2α but only thymol was able to reduced exhaled nitric oxide (p < 0.05). Conclusion: Monoterpenes p-cymene, carvacrol and thymol reduced lung emphysema and inflammation in mice. No significant differences among the three monoterpenes treatments were found, suggesting that the presence of hydroxyl group in the molecular structure of thymol and carvacrol do not play a central role in the anti-inflammatory effects.
| Reference Key |
games2016moleculesstructurally
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| Authors | ;Ellen Games;Marina Guerreiro;Fernanda R. Santana;Nathalia M. Pinheiro;Emerson A. de Oliveira;Fernanda D.T.Q.S. Lopes;Clarice R. Olivo;Iolanda F.L.C. Tibério;Mílton A. Martins;João Henrique G. Lago;Carla M. Prado |
| Journal | Journal of ethnopharmacology |
| Year | 2016 |
| DOI |
10.3390/molecules21101390
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| URL | |
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