de-novo cd5 + b- prolymphocytic leukemia (pll) presenting at younger age with favourable outcome

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ID: 246731
2008
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Abstract
B-cell prolymphocytic leukemia (B-PLL) comprises 1% of chronic lymphocytic leukemias. CD5 positivity is seen in 1/3rd of cases which generally arise from pre existing CLL. They have longer median survival compared with de novo B-PLL which are commonly CD5 negative and are more aggressive with an older age of presentation. Herewith, we describe a 48-year-old male of de-novo CD5+ B-PLL presenting with minimal lymphadenopathy and massive splenomegaly with 90% atypical lymphoid cells in the peripheral smear and bone marrow. Immunophenotyping was strongly positive for CD5, CD45, CD19, CD22, FMC-7, S-Ig and CD38, moderately positive for CD 11c, weakly positive for CD23 and negative for CD-103 and ZAP 70. The patient responded well to fludarabine and cyclophosphamide and had an uneventful hospital course. Our case illustrates a de-novo B-PLL with aberrant CD5 positivity who had a short duration of illness, younger age at presentation and favourable treatment outcome.
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Authors Seema Tyagi, Rajat Kumar, Rakhee Kar
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Journal proceedings of the international conference on iot in social, mobile, analytics and cloud, i-smac 2017
Year 2008
DOI
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URL
http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-54154
Keywords
prognosis prolymphocytic leukemia internal medicinediseases of the blood and blood-forming organs

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