avaliação terapêutica do artesunato na infecção experimental pelo schistosoma mansoni therapeutical evaluation of the artesunate in experimental schistosoma mansoni infection

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ID: 246207
1999
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Abstract
Camundongos infectados experimentalmente com Schistosoma mansoni foram tratados, em dose oral única, com artesunato (LACTAB®), 300 ou 500mg/kg ou durante cinco dias consecutivos. Os animais foram sacrificados 7, 30, 60 ou 90 dias após o tratamento. Diferenças estatisticamente significativas foram encontradas na distribuição e mortalidade dos vermes e na alteração do oograma nos grupos tratados quando comparados ao controle, em todos os esquemas testados quando os animais foram sacrificados 30 dias após o tratamento. A análise morfológica dos vermes mostrou alterações no aparelho reprodutor feminino com diminuição do volume ovariano, rarefação dos folículos vitelínicos, alterações estas mais acentuadas nas dosagens mais altas, justificando o encontro na alteração do oograma que chegou a 100%. Entretanto, quando os animais foram sacrificados 60 ou 90 dias após o tratamento, as diferenças e alterações foram menores, mostrando que os vermes sobreviventes se recuperaram e reiniciaram a postura.
Mice experimentally infected with Schistosoma mansoni were treated orally with artesunate (Lactab®) in a single dose of 300 or 500mg/kg or over a period of five consecutive days. The animals were sacrificed 7, 30, 60 or 90 days after treatment. Statistically significant differences were found in the distribution and mortality of the worms and in the alterations of the oogram in the treated group when compared to control in all of the tested schemes when the animals were sacrificed 30 days after treatment. Morphological analysis of female worms showed a reduction of ovarian volume and rarefaction of the vitelline follicles. These modifications were more marked after treatment with the higher dose, explaining the alteration of the oogram which reached 100%. However, when the animals were sacrificed 60 or 90 days after treatment, the differences and alterations were smaller, showing that the surviving worms recovered and restarted oviposition.
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arajo1999revistaavaliao Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Neusa Araújo, Anna Kohn, Naftale Katz
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Journal mobile information systems
Year 1999
DOI
10.1590/S0037-86821999000100002
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821999000100002
Keywords
diabetes mellitus primary health care schistosoma mansoni tropical medicine epidemiology surveillancepublic aspects of medicine

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