avaliação terapêutica do artesunato na infecção experimental pelo schistosoma mansoni therapeutical evaluation of the artesunate in experimental schistosoma mansoni infection
Clicks: 186
ID: 246207
1999
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
30.0
/100
186 views
8 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #134 of 272 articles by views in mobile information systems
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 272 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Camundongos infectados experimentalmente com Schistosoma mansoni foram tratados, em dose oral única, com artesunato (LACTAB®), 300 ou 500mg/kg ou durante cinco dias consecutivos. Os animais foram sacrificados 7, 30, 60 ou 90 dias após o tratamento. Diferenças estatisticamente significativas foram encontradas na distribuição e mortalidade dos vermes e na alteração do oograma nos grupos tratados quando comparados ao controle, em todos os esquemas testados quando os animais foram sacrificados 30 dias após o tratamento. A análise morfológica dos vermes mostrou alterações no aparelho reprodutor feminino com diminuição do volume ovariano, rarefação dos folículos vitelínicos, alterações estas mais acentuadas nas dosagens mais altas, justificando o encontro na alteração do oograma que chegou a 100%. Entretanto, quando os animais foram sacrificados 60 ou 90 dias após o tratamento, as diferenças e alterações foram menores, mostrando que os vermes sobreviventes se recuperaram e reiniciaram a postura.
Mice experimentally infected with Schistosoma mansoni were treated orally with artesunate (Lactab®) in a single dose of 300 or 500mg/kg or over a period of five consecutive days. The animals were sacrificed 7, 30, 60 or 90 days after treatment. Statistically significant differences were found in the distribution and mortality of the worms and in the alterations of the oogram in the treated group when compared to control in all of the tested schemes when the animals were sacrificed 30 days after treatment. Morphological analysis of female worms showed a reduction of ovarian volume and rarefaction of the vitelline follicles. These modifications were more marked after treatment with the higher dose, explaining the alteration of the oogram which reached 100%. However, when the animals were sacrificed 60 or 90 days after treatment, the differences and alterations were smaller, showing that the surviving worms recovered and restarted oviposition.
Mice experimentally infected with Schistosoma mansoni were treated orally with artesunate (Lactab®) in a single dose of 300 or 500mg/kg or over a period of five consecutive days. The animals were sacrificed 7, 30, 60 or 90 days after treatment. Statistically significant differences were found in the distribution and mortality of the worms and in the alterations of the oogram in the treated group when compared to control in all of the tested schemes when the animals were sacrificed 30 days after treatment. Morphological analysis of female worms showed a reduction of ovarian volume and rarefaction of the vitelline follicles. These modifications were more marked after treatment with the higher dose, explaining the alteration of the oogram which reached 100%. However, when the animals were sacrificed 60 or 90 days after treatment, the differences and alterations were smaller, showing that the surviving worms recovered and restarted oviposition.
| Reference Key |
arajo1999revistaavaliao
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Neusa Araújo;Anna Kohn;Naftale Katz |
| Journal | mobile information systems |
| Year | 1999 |
| DOI |
10.1590/S0037-86821999000100002
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.