toxicity and management in car t-cell therapy

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2016
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Abstract
T cells can be genetically modified to target tumors through the expression of a chimeric antigen receptor (CAR). Most notably, CAR T cells have demonstrated clinical efficacy in hematologic malignancies with more modest responses when targeting solid tumors. However, CAR T cells also have the capacity to elicit expected and unexpected toxicities including: cytokine release syndrome, neurologic toxicity, “on target/off tumor” recognition, and anaphylaxis. Theoretical toxicities including clonal expansion secondary to insertional oncogenesis, graft versus host disease, and off-target antigen recognition have not been clinically evident. Abrogating toxicity has become a critical step in the successful application of this emerging technology. To this end, we review the reported and theoretical toxicities of CAR T cells and their management.
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bonifant2016moleculartoxicity Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Challice L Bonifant, Hollie J Jackson, Renier J Brentjens, Kevin J Curran
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Journal neurology india
Year 2016
DOI
10.1038/mto.2016.11
URL
http://www.sciencedirect.com/science/article/pii/S2372770516300353
Keywords
neoplasms Oncology including cancer and carcinogens tumors

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