assessing risk of bias in randomized controlled trials for autism spectrum disorder
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2017
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Abstract
AimTo determine construct validity and reliability indicators of the Cochrane risk of bias (RoB) tool in the context of randomized clinical trials (RCTs) for autism spectrum disorder (ASD).MethodsConfirmatory factor analysis was used to evaluate a unidimensional model consisting of 9 RoB categorical indicators evaluated across 94 RCTs addressing interventions for ASD.ResultsOnly five of the nine original RoB items returned good fit indices and so were retained in the analysis. Only one of this five had very high factor loadings. The remaining four indicators had more measurement error than common variance with the RoB latent factor. Together, the five indicators showed poor reliability (ω = 0.687; 95% CI: 0.613–0.761).ConclusionAlthough the Cochrane model of RoB for ASD exhibited good fit indices, the majorities of the items have more residual variance than common variance and, therefore, did not adequately capture the RoB in ASD intervention trials.
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okuda2017frontiersassessing
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| Authors | ;Paola Matiko Martins Okuda;Cheryl Klaiman;Cheryl Klaiman;Jessica Bradshaw;Jessica Bradshaw;Morganne Reid;Hugo Cogo-Moreira |
| Journal | journal of experimental psychology general |
| Year | 2017 |
| DOI |
10.3389/fpsyt.2017.00265
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