deep brain stimulation of the pallidum is effective and might stabilize striatal d2 receptor binding in myoclonus-dystonia.
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ID: 245824
2012
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Abstract
Purpose: To assess clinical efficacy of deep brain stimulation of the pallidum in Myoclonus-Dystonia patients, and to compare pre- and postoperative striatal dopamine D2 receptor availability.Methods: Clinical parameters were scored using validated rating scales for myoclonus and dystonia. Dopamine D2 receptor binding of three patients was studied before surgery and approximately two years post-operatively using 123I-iodobenzamide Single Photon Emission Computed Tomography. Two patients who did not undergo surgery served as controls.Results: Clinically, the 3 Myoclonus-Dystonia patients improved 83%, 17% and 100%, respectively on the myoclonus rating scale and 78%, 23% and 65% on the dystonia rating scale after deep brain stimulation. Dopamine D2 receptor binding did not change after surgery. In the two control subjects, binding has lowered further.Conclusions: These findings confirm that deep brain stimulation of the pallidum has beneficial effects on motor symptoms in Myoclonus-Dystonia and suggest this procedure might stabilize dopamine D2 receptor binding.
| Reference Key |
beukers2012frontiersdeep
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| Authors | ;Richard J. Beukers;Maria Fiorella Contarino;Hans D Speelman;P. Rick Schuurman;Jan eBooij;Marina A.J. Tijssen |
| Journal | journal of photochemistry and photobiology a: chemistry |
| Year | 2012 |
| DOI |
10.3389/fneur.2012.00022
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| URL | |
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