release of prostaglandin d2 by murine mast cells: importance of metabolite formation for antiproliferative activity

Clicks: 291
ID: 245802
1998
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Abstract
Prostaglandin (PG) D2 , PGJ2 and Δ12 -PGJ2 are antiproliferative eicosanoids. We investigated the production of PGD2 by murine bone marrow-derived mast cells (BMMC) taking into consideration metabolism of PGD2 to PGD2 and Δ12-PGJ2. PG-metabolites were quantified by high performance liquid chromatography (HPLC) combined with radioimmunoassay (RIA). Stimulated with calcium ionophore A23187 BMMC released eight-fold more PGJ2 and Δ12-PGJ2 than PGD2. Conversion of endogenously produced PGD2 to PGJ2 and Δ12-PGJ2 proceeded rapidly in contrast to metabolism of exogenously added PGD2. The antiproliferative potency of these prostaglandins is demonstrated in vitro. We conclude that determination of PGD2 production by mast cells must take into consideration rapid conversion to active derivatives, which may play a significant role in growth regulation.
Reference Key
haberl1998mediatorsrelease Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;C. Haberl;L. Hültner;A. Flügel;M. Falk;S. Geuenich;W. Wilmanns;C. Denzlinger
Journal polyhedron
Year 1998
DOI
10.1080/09629359891216
URL
http://dx.doi.org/10.1080/09629359891216
Keywords
pathology anti-proliferative activity mast cell Δ12-prostaglandin j2

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