mild hypothermia reduces expression of fas/fasl and mmp-3 after cerebral ischemia-reperfusion in rats
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2014
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Abstract
Objective(s):To investigate the effects of local mild hypothermia on the expression of Fas, FasL and MMP-3 after cerebral ischemia-reperfusion in rats. Materials and Methods:Male Wistar rats were divided into sham-operated group (Sham), normothermia group (NT), and hypothermia group (HT). MCAO/R model was established by Longa’s method, and reperfusion was allowed after 2 hr occlusion. Mild hypothermia (33±0.5℃) for 6 hr was initiated at the start of reperfusion. Immunohistochemistry was performed to determine expression Fas, FasL, and MMP-3. Results: Infarct volume was reduced in the hypothermia group (18.43±4.23%) compared with the normothermia group (24.76±5.76%) (P
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| Reference Key |
zhao2014iranianmild
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| Authors | ;Jingkun Zhao;Shurong Duan;Jinxia Zhou;Ruihong Sun;Liming Zhang;Desheng Wang |
| Journal | PloS one |
| Year | 2014 |
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