increased frequency of circulating follicular helper t cells in children with hand, foot, and mouth disease caused by enterovirus 71 infection
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2014
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Abstract
Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD) in children. The role of T follicular helper (TFH) cells in EV71-infected children remains unclear in regulating humoral immunity. The frequency of circulating ICOShigh/PD-1highCXCR5+CD4+ TFH cells in the children with mild and severe EV71 infection and healthy controls (HC) was detected by flow cytometry, respectively. IL-21 and IL-6 mRNA expression and their serum levels, Bcl-6 mRNA expression, and specific neutralizing antibodies against EV71 (NAb-EV71) were measured. In the acute stage of patients with EV71 infection, increased frequencies of circulating TFH cells with ICOShigh and PD-1high expression in the mild and severe patients were observed, and the positive correlations among the frequencies of circulating TFH cells and the serum levels of IL-21, IL-6, and NAb-EV71 titres were detected, respectively. Moreover, the expressions of IL-6 and IL-21 mRNA in PBMCs from patients were also significantly higher than those of HC. However, further analysis did not reveal any significant differences between mild and severe patients. These data indicate a role of TFH cells and associated cytokines in modulating the humoral response during the pathogenesis of EV71 infection.
| Reference Key |
wu2014journalincreased
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| Authors | ;Jianping Wu;David Cui;Xianzhi Yang;Jianzhou Lou;Jie Lin;Xianfei Ye;Zhimei Qin;Li Huang;Dejian Zhao;Zhaoxia Huo;Guoliang Xie;Shufa Zheng;Fei Yu;Liwei Lu;Yu Chen |
| Journal | journal of photochemistry and photobiology b, biology |
| Year | 2014 |
| DOI |
10.1155/2014/651872
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| URL | |
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