molecular mechanisms of long ncrnas in neurological disorders

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ID: 245554
2014
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Abstract
Long non-coding RNAs (ncRNAs) have added an unexpected layer of complexity in the regulation of gene expression. Mounting evidence now links long ncRNAs to fundamental biological processes such as development and differentiation, and recent research shows important involvement of long ncRNAs in a variety of diseases including neurodegenerative disorders, such as Parkinson’s, Alzheimer’s, spinocerebellar ataxia and Huntington’s diseases. Furthermore, long ncRNAs are speculated to be implicated in development of psychiatric disorders such as schizophrenia and bipolar disorders. Long ncRNAs contribute to these disorders in diverse ways, from regulation of transcription to modulation of RNA processing and translation. In this review, we describe the diverse mechanisms reported for long ncRNAs, and discuss how they could mechanistically be involved in the development of neurological disorders.
Reference Key
evuievi2014frontiersmolecular Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Dubravka eVučićević;Heinrich eSchrewe;Ulf eAndersson Ørom
Journal chemical record (new york, ny)
Year 2014
DOI
10.3389/fgene.2014.00048
URL
http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00048/full
Keywords
ncrna brain development neurological disorders protein-rna interaction long noncoding rnagenetics

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