brca1 and brca2 mutations in iranian breast cancer patients: a systematic review

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2015
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Abstract
Background: BRCA1/2 genes mutation prevalence varies among ethnic groups and may be influenced by founder mutations. Understanding BRCA1/2 genes mutations is important for reducing breast cancer (BC) incidence, accurate risk assessment and counseling. This systematic review of the literature was conducted to addressing BRCA1/2 mutations in Iranian BC patients. Materials and Methods: A search for relevant articles was run on before January 2014 using MedLine, PubMed, Science Iranian Database, Google, and Web sites related to the study topic. The key words included: BC and Iran with Genes, BRCA Genes, BRCA1 and BRCA2; "Cancer Genes," and "Iran." Results: Thirteen articles retrieved from this search strategy were eligible for this review. The overall BRCA1 mutation rate for Iranian female BC patients was detected 31.8% (377/1183). Although this gene mutation rate for male patients is <0.01%. Eight BRCA1 mutations (c. 4837A > G, c. 3419G > A, c. 3119G > A, c. 2612C > T, c. 3113A > G, c. 2311T > C, c. 4301T > C and c. 4308T > C in BRCA1, and one BRCA2 mutation (c. 6494G > C) were found in multiple case subjects and represent candidate founder mutations. Conclusion: According to these studies, there is heterogeneity in BRCA mutations in Iranian BC patients.
Reference Key
neamatzadeh2015journalbrca1 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Hossein Neamatzadeh;Seyed Mostafa Shiryazdi;Seyed Mahdi Kalantar
Journal 2017 ieee international conference on communication, networks and satellite, comnetsat 2017 - proceedings
Year 2015
DOI
DOI not found
URL
http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2015;volume=20;issue=3;spage=284;epage=293;aulast=Neamatzadeh
Keywords
Breast cancer brca1 brca2 iranmedicine

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