propylthiouracil-induced acute liver failure: role of liver transplantation

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ID: 245178
2010
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Abstract
Propylthiouracil- (PTU-) induced hepatotoxicity is rare but potentially lethal with a spectrum of liver injury ranging from asymptomatic elevation of transaminases to fulminant hepatic failure and death. We describe two cases of acute hepatic failure due to PTU that required liver transplantation. Differences in the clinical presentation, histological characteristics, and posttransplant management are described as well as alternative therapeutic options. Frequent monitoring for PTU-induced hepatic dysfunction is strongly advised because timely discontinuation of this drug and implementation of noninvasive therapeutic interventions may prevent progression to liver failure or even death.
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carrion2010internationalpropylthiouracil-induced Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Andres F. Carrion;Frank Czul;Leopoldo R. Arosemena;Gennaro Selvaggi;Monica T. Garcia;Akin Tekin;Andreas G. Tzakis;Paul Martin;Ravi K. Ghanta
Journal zhonghua wei zhong bing ji jiu yi xue
Year 2010
DOI
10.1155/2010/910636
URL
http://dx.doi.org/10.1155/2010/910636
Keywords
clinical endocrinology diseases of the endocrine glands

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