association of certain endothelial function indicators with t894g polymorphism of endothelial nitric oxide synthase gene in patients with hypothyroidism and concomitant chronic cholecystitis

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ID: 245088
2016
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Abstract
The association of the T894G endothelial nitric oxide synthase (eNOS) gene polymorphism with certain indicators of endothelial function in patients with hypothyroidism and concomitant chronic non-calculous cholecystitis was investigated. Significant increase by 33.1 % (P = 0.01) of desquamated endothelial cells number in the blood was found in patients with T-allele compared with that of in GG-genotype carriers. Also, the concentration of total nitric oxide stable metabolites was 10.4 % (P = 0.04) higher and the level of nitrate anions in the blood was 10.8 % (P = 0.02) higher than in comparison group. Among patients with hypothyroidism and concomitant chronic cholecystitis, the content of vascular endothelial growth factor was 27.7 % (P = 0.03) higher in T-allele carriers as compared with patients with GG-genotype.
Reference Key
prysiazhniuk2016mnarodnijassociation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;I.V. Prysiazhniuk;N.V. Pashkovska
Journal Macromolecular rapid communications
Year 2016
DOI
10.22141/2224-0721.2.74.2016.70935
URL
http://iej.zaslavsky.com.ua/article/view/70935
Keywords
hypothyroidism vascular endothelial growth factor clinical endocrinology diseases of the endocrine glands

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