evaluation of neural gene expression in serum treated embryonic stem cells in alzheimer′s patients

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ID: 244662
2013
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Ranked #102 of 133 articles by views in 2017 ieee international conference on communication, networks and satellite, comnetsat 2017 - proceedings

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Abstract
Background: Previous studies confirmed that neural gene expression in embryonic stem cells (ESC) could influence by chemical compounds through stimulating apoptotic pathway. We aimed to use ESCs-derived neural cells by embryoid body formation as an in vitro model for determination of neural gene expression changes in groups that treated by sera from Alzheimer′s patients and compare with healthy individuals. Materials and Methods: ESC line which was derived from the C57BL/6 mouse strain was used throughout this study. ESC-derived neural cells were treated with serum from Alzheimer′s patient and healthy individual. Neural gene expression was assessed in both groups by quantitative real-time polymerase chain reaction analysis. The data was analyzed by SPSS Software (version 18). Results: Morphologically, the reducing in neurite out-growth was observed in neural cells in group, which treated by serum from Alzheimer′s patient, while neurite growth was natural in appearance in control group. Microtubule-associated protein 2 and glial fibrillary acidic protein expression significantly reduced in the Alzheimer′s patient group compared with the control group. Nestin expression did not significantly differ among the groups. Conclusion: Neural gene expression could be reduced in serum treated ESC in Alzheimer′s patients.
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dehghani2013journalevaluation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Leila Dehghani;Batool Hashemi-Beni;Elahe Poorazizi;Fariborz Khorvash;Vahid Shaygannejad;Maryam Sedghi;Sahar Vesal;Rokhsareh Meamar
Journal 2017 ieee international conference on communication, networks and satellite, comnetsat 2017 - proceedings
Year 2013
DOI
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URL
http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=13;spage=20;epage=23;aulast=Dehghani
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