is fibroblast growth factor 23 the leading cause of increased mortality among chronic kidney disease patients? a narrative review

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2017
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Abstract
The death rate among chronic kidney disease patients is the highest compared to other chronic diseases. 60% of these fatalities are cardiovascular. Cardiovascular calcifications and chronic inflammation affect almost all chronic kidney disease patients and are associated with cardiovascular mortality. Fibroblast growth factor 23 is associated with vascular calcification. Systemic inflammation in chronic kidney disease patients is multifactorial. The role of systemic inflammation in the pathogenesis of vascular calcification was recently reappraised. Fibroblast growth factor 23 was accused as a direct stimulus of left ventricular hypertrophy, uremic inflammation, and impaired neutrophil function. This review will discuss the underlying mechanisms that underlie the link between Fibroblast growth factor 23 and increased mortality encountered among chronic kidney disease patients.
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din2017journalis Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Usama A.A. Sharaf El Din;Mona M. Salem;Dina O. Abdulazim
Journal reading & writing
Year 2017
DOI
10.1016/j.jare.2017.02.003
URL
http://www.sciencedirect.com/science/article/pii/S2090123217300279
Keywords
inflammation chronic kidney disease fibroblast growth factor 23 vascular calcification left ventricular hypertrophy

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