comparison of human adipose-derived stem cells and chondroitinase abc transplantation on locomotor recovery in the contusion model of spinal cord injury in rats
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2014
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Abstract
Objective(s):Spinal cord injury (SCI) is one of the most serious clinical diseases and its treatment has been a subject of interest to researchers. There are two important therapeutic strategies in the treatment of SCI: replacing lost tissue cells through cells implantation and scar elimination. Therefore, in this study we used human adipose-derived stem cells (hADSCs) implantation and injection of Chondroitinase ABC. Aim of present study was to answer to this question: which one is more efficient for Improvement of locomotor recovery after SCI in rat? Transplantation of hADSCs or injection of ChABC. Materials and Methods: The spinal cord of rats was injured by contusion using a weight-drop at the level of T8-9, the hADSCs and Chondroitinase ABC were infused in to the spinal cord tissue after injury. BBB test was performed and recorded for each animal weekly for 8 weeks. After the 8th weeks, Serial cross-sections were stained with cresyl violet and examined under a light microscope and area of cavity in the spinal cord was measured. Results: At 8th weeks after injection, hADSCs and ChABC significantly promote locomotor function (P
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sarveazad2014iraniancomparison
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| Authors | ;Arash Sarveazad;Mehrdad Bakhtiari;Asrin Babahajian;Atusa Janzade;Ali Fallah;Fatemeh Moradi;Mansoureh Soleimani;Mohammadreza Younesi;Farjam Goudarzi;Mohammad Taghi Joghataei |
| Journal | PloS one |
| Year | 2014 |
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