staging of colorectal cancer using serum metabolomics with 1hnmr spectroscopy
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ID: 244431
2017
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Abstract
Objective(s): Determination of stages of colon cancer is done by biopsy usually after surgery. Metabolomics is the study of all the metabolites using LC-MS and 1HNMR spectroscopy with chemometric techniques. The stages of colon cancer were detected from patients' sera using 1HNMR. Materials and Methods: Five ml blood was collected from 16 confirmed patients referred for colonoscopy. One group of eight patients were diagnosed with stage 0 to I colon cancer and the second group of 8 patients with II-IV stage colon cancer. Sera were sent for 1HNMR. The differentiating metabolites were identified using HMDB and the metabolic cycles from Metaboanalyst. Results: Six metabolites of which pyridoxine levels lowered, and glycine, cholesterol, taurocholic acid, cholesteryl ester and deoxyinosine increased. Conclusion: The different stages of cancer were identified by the main metabolic cycles such as primary bile acid biosynthesis, purine and vitamin B metabolic pathways and the glutathione cycle.
| Reference Key |
vahabi2017iranianstaging
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| Authors | ;Farideh Vahabi;Sedigheh Sadeghi;Mohammad Arjmand;Fatemeh Mirkhani;Eshagh Hosseini;Mahsheed Mehrabanfar;Reza Hajhosseini;Ayda Iravani;Parastou Bayat;Zahra Zamani |
| Journal | PloS one |
| Year | 2017 |
| DOI |
10.22038/ijbms.2017.9022
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| URL | |
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