In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations.

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ID: 2442
2018
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Abstract
The aim of this study is to evaluate the antihyperalgesic and antinociceptive effects of two formulations containing peat water extracts using a model of carrageenan-induced hyperalgesia, combined with a test with a mechanical stimulus, and a hot plate test. Rats were divided into seven groups (n = 6) and received local treatment with two peat formulations and two diclofenac formulations dissolved in carbopol gel and Wolff® basis creme, respectively. Carbopol gel, Wolff® basis creme and 0.9 % NaCl without tested substances were used as controls. Both peat formulations exerted an unambiguous antihyperalgesic effect 60 minutes after the treatment. In the hot plate test, the rats treated with the Wolff® basis creme peat formulation showed a tendency to prolonged latency on the first hour. The results could be explained by partial activation of peripheral α2-adrenoceptors and the possible COX-2 suppressive activity.
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zagorchev2018inacta Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zagorchev, Plamen Ivanov;Apostolova, Elisaveta Georgieva;Pilicheva, Bissera Asenova;Draganova-Filipova, Milena Nenkova;Kokova, Vesela Yulieva;Lukanov, Julian Borisov;
Journal acta pharmaceutica
Year 2018
DOI
10.2478/acph-2018-0029
URL
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