melatonin attenuates contrast-induced nephropathy in diabetic rats: the role of interleukin-33 and oxidative stress

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ID: 244103
2016
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Abstract
Background. Inflammation and oxidative stress (OxS) contribute to the pathogenesis of diabetic kidney disease (DKD) and contrast-induced nephropathy (CIN). Patients with DKD were found to be more prone to CIN. Interleukin-33 (IL-33) is a proinflammatory cytokine, but its role in DKD and CIN is unknown. Methods. Thirty male Sprague-Dawley rats were enrolled. The first group was comprised of healthy rats (HRs), whereas the other four groups were made up of diabetic rats (DRs), diabetic rats with contrast-induced nephropathy (CIN + DRs), melatonin-treated diabetic rats (MTDRs), and melatonin-treated CIN + DRs (MTCIN + DRs). All groups except the HRs received 50 mg/kg/day streptozotocin (STZ). CIN + DRs were constituted by administrating 1.5 mg/kg of intravenous radiocontrast dye on the 35th day. MTDRs and MTCIN + DRs were given 20 mg/kg/day of intraperitoneal injection of melatonin (MT) from the 28th day for the constitutive seven days. Results. We observed increased IL-33 in the kidney tissue following induction of CIN in DRs. To determine whether MT is effective in preventing CIN, we administered MT in CIN + DRs and demonstrated that kidney tissue levels of OxS markers, inflammatory cytokines, and IL-33 were significantly diminished in MTCIN + DRs compared with other groups without MT treatment (p<0.05). Conclusion. Inhibition of IL-33 with MT provides therapeutic potential in DKD with CIN.
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onk2016mediatorsmelatonin Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Didem Onk, Oruc Alper Onk, Kultigin Turkmen, Huseyin Serkan Erol, Tulin Akarsu Ayazoglu, Osman Nuri Keles, Mesut Halici, Ergun Topal
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Journal polyhedron
Year 2016
DOI
10.1155/2016/9050828
URL
http://dx.doi.org/10.1155/2016/9050828
Keywords
pathology

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