potential application of tregitopes as immunomodulating agents in multiple sclerosis

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ID: 243991
2011
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Abstract
The induction of immunologic tolerance is an important clinical goal in autoimmunity. CD4+ regulatory T (Treg) cells, defined by the expression of the transcription factor forkhead box P3 (FoxP3), play a central role in the control of autoimmune responses. Quantitative and qualitative defects of Tregs have been postulated to contribute to failed immune regulation in multiple sclerosis (MS) and other autoimmune diseases. This paper highlights the potential uses of T regulatory cell epitopes (Tregitopes), natural Treg epitopes found to be contained in human immunoglobulins, as immunomodulating agents in MS. Tregitopes expand Treg cells and induce “adaptive Tregs” resulting in immunosuppression and, therefore, are being considered as a potential therapy for autoimmune diseases. We will compare Tregitopes versus intravenous immunoglobulin (IVIg) in the treatment of EAE with emphasis on the potential applications of Tregitope for the treatment of MS.
Reference Key
elyaman2011neurologypotential Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wassim Elyaman, Samia J. Khoury, David W. Scott, Anne S. De Groot
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Journal Clinical oral investigations
Year 2011
DOI
10.1155/2011/256460
URL
http://dx.doi.org/10.1155/2011/256460
Keywords
neurology diseases of the nervous system

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