maintained smoking cessation for 6 months equilibrates the percentage of sputum cd8+ lymphocyte cells with that of nonsmokers
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ID: 243673
2009
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Abstract
Little is known about the longitudinal effects of smoking cessation on sputum inflammatory cells. We aimed to investigate the changes in sputum inflammatory cells and T-lymphocyte subpopulations after 6 and 12 months smoking cessation. Induced sputum was obtained from 68 healthy smokers before and after 6 months (n=21) and 1 year (n=14) smoking cessation and from ten healthy never-smokers. Inflammatory cells were identified by morphology and T-lymphocyte subpopulations by flow cytometry. Sputum macrophages were decreased after 12 months of smoking cessation in comparison to baseline, while neutrophils increased. Moreover, CD8+ T-cells were decreased in smokers before smoking cessation compared to never-smokers and increased in smokers after 6 months of smoking cessation in comparison to baseline; result that was maintained after 1 year of smoking cessation. These novel findings indicate that smoking cessation can equilibrate certain inflammatory cells of smokers with those of nonsmokers, within 6 months of smoking cessation.
| Reference Key |
bouloukaki2009mediatorsmaintained
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|---|---|
| Authors | ;Izolde Bouloukaki;Maria Tsoumakidou;Constantine I. Vardavas;Ioanna Mitrouska;Eleni Koutala;Nikolaos M. Siafakas;Sophia E. Schiza;Nikos Tzanakis |
| Journal | polyhedron |
| Year | 2009 |
| DOI |
10.1155/2009/812102
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| URL | |
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