hyperbilirubinemia without transaminitis during combined therapy with daclatasvir and asunaprevir

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ID: 243242
2016
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Abstract
Daclatasvir (DCV) and asunaprevir (ASV) are direct-acting antivirals (DAAs) used in the treatment of chronic hepatitis C virus (HCV) infection. Combined therapy with DCV and ASV shows high efficacy and safety even in patients with cirrhosis. We encountered a patient exhibiting severe hyperbilirubinemia during combined therapy, which is an unreported side effect of DCV and ASV. A 78-year-old woman with cirrhosis developed hyperbilirubinemia >10 mg/dl without transaminitis 3 weeks after starting combined therapy. We suspected DAAs-induced liver disorder and discontinued treatment, which resulted in the improvement of hyperbilirubinemia. Caution is required in the use of DAAs for patients with advanced cirrhosis.
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baba2016casehyperbilirubinemia Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Hayato Baba;Kazuto Tajiri;Kohei Nagata;Kengo Kawai;Masami Minemura;Toshiro Sugiyama
Journal trends in genetics : tig
Year 2016
DOI
10.1159/000447486
URL
http://www.karger.com/Article/FullText/447486
Keywords
hepatitis c virus cirrhosis p-glycoprotein Gastroenterology hyperbilirubinemiadiseases of the digestive system

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