synthesis and in vitro antiproliferative activity of novel androst-5-ene triazolyl and tetrazolyl derivatives
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ID: 243220
2011
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Abstract
A straightforward and reliable method for the regioselective synthesis of steroidal 1,4-disubstituted triazoles and 1,5-disubstituted tetrazoles via copper(I)-catalyzed cycloadditions is reported. Heterocycle moieties were efficiently introduced onto the starting azide compound 3β-acetoxy-16β-azidomethylandrost-5-en-17β-ol through use of the “click” chemistry approach. The antiproliferative activities of the newly-synthesized triazoles were determined in vitro on three human gynecological cell lines (HeLa, MCF7 and A2780) using the microculture tetrazolium assay.
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wlfling2011moleculessynthesis
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| Authors | ;János Wölfling;Tibor Bartók;Éva Frank;Gyula Schneider;Judit Huber;István Zupkó;Dóra Kovács;Zalán Kádár |
| Journal | Journal of ethnopharmacology |
| Year | 2011 |
| DOI |
10.3390/molecules16064786
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