biodistribution of the radiopharmaceutical sodium pertechnetate after biliopancreatic bypass with a duodenal switch

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ID: 243139
2007
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Abstract
Study with the purpose to examine the effects of duodenal switch (DS), regularly performed in morbidly obese patients, on biodistribution of sodium pertechnetate in several organs of rats. There was no early or late mortality in either rats groups. The values of percent radioactivity per gram of tissue (%ATI/g), showed no significant difference in liver, stomach, small bowel, duodenum, kidney, heart, bladder, bone and brain, when compared the DS rats with sham and controls rats. A postoperative significant increase (p<0.05) in mean %ATI/g levels was observed in spleen, pancreas and muscle in group DS rats, as compared to group S and C rats. In the lung there was an increase and in thyroid a decrease in mean %ATI/g of DS rats, when compared to sham rats (p<0.05). In conclusion, the biliopancreatic diversion with duodenal switch in rats modified the biodistribution of sodium pertechnetate in thyroid, lung, pancreas, spleen and muscle.
Estudo objetivando examinar efeitos do procedimento cirúrgico switch duodenal (SD) na biodistribuição do pertecnetato de sódio em vários órgãos de ratos. Não ocorreu mortalidade precoce e tardia nos animais operados. Os valores do percentual de radioatividade/grama de tecido (%ATI/g) mostraram nenhuma diferença significativa no fígado, estômago, intestino, duodeno, rim, coração, bexiga, osso e cérebro, comparando-se o grupo SD com sham e controle. Aumento significativo (p<0,05) na média de %ATI/g foi observado no baço, pâncreas e músculo (grupo SD), comparado com os grupos sham e controle. No pulmão houve aumento e na tireóide diminuição no %ATI/g nos ratos SD, comparados com os sham e controles (p>0,05). Em conclusão, a cirurgia denominada derivação biliopancreática com switch duodenal em ratos modificou a biodistribuição de pertecnetato de sódio na tireóide, pulmão, pâncreas, baço e músculo, podendo significar que a interpretação de exames cintilográficos nesses órgãos deve ser feita com cautela.
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Authors Irami Araújo-Filho, Amália Cínthia Meneses Rêgo, José Brandão-Neto, Arthur Villarim-Neto, Eryvaldo Sócrates Tabosa Egito, Ítalo Medeiros Azevedo, Aldo Cunha Medeiros
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Journal current drug delivery
Year 2007
DOI
10.1590/S1516-89132007000600024
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000600024
Keywords
bariatric surgery

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