role of mirnas in cd4 t cell plasticity during inflammation and tolerance

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ID: 242744
2013
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Abstract
Gene expression is tightly regulated in a tuneable, cell-specific and time-dependent manner. Recent advancement in epigenetics and non-coding RNA revolutionized the concept of gene regulation. In order to regulate the transcription, non-coding RNA (ncRNA) can promptly response to the extracellular signals as compared to transcription factors present in the cells. microRNAs (miRNAs) are non-coding RNA (~22 bp) encoded in the genome, and present as intergenic or oriented antisense to neighboring genes. The strategic location of miRNA in coding genes helps in the coupled regulation of its expression with host genes. miRNA together with complex machinery called RNA-induced silencing complex (RISC) interacts with target mRNA and degrade the mRNA or inhibits the translation. CD4 T cells play an important role in the generation and maintenance of inflammation and tolerance. Cytokines and chemokines present in the inflamed microenvironment controls the differentiation and function of various subsets of CD4 T cells (Th1, Th2, Th17 and Tregs). Recent studies suggest that miRNAs play an important role in the development and function of all subsets of CD4 T cells. In current review, we focused on how various miRNAs are regulated by cell’s extrinsic and intrinsic signalling, and how miRNAs affect the transdifferentiation of subsets of CD4 T cell and controls their plasticity during inflammation and tolerance.
Reference Key
esethi2013frontiersrole Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Apoorva eSethi;Neeraja eKulkarni;Sandip eSonar;Girdhari eLal
Journal chemical record (new york, ny)
Year 2013
DOI
10.3389/fgene.2013.00008
URL
http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00008/full
Keywords
genetics tolerance non-coding rna mirna th17 cells

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