elevated serum gamma-glutamyltransferase is a strong marker of insulin resistance in obese children

Clicks: 102
ID: 242633
2013
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #139 of 149 articles by views in zhonghua wei zhong bing ji jiu yi xue

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 149 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Elevated levels of serum gamma-glutamyltransferase (GGT) levels have been found to predict the development of type 2 diabetes in adults. The role of GGT in insulin resistance (IR) among children is largely unknown. We investigated whether GGT among hepatic enzymes is independently associated with IR in obese Korean children. A total of 1308 overweight (above the 85th BMI percentile of Korean reference) boys (n=822) and girls (n=486), aged 9–15 years, were studied. Measures acquired included weight, height, percent body fat (BF%), waist circumference, blood pressure, blood glucose and insulin, C-reactive protein, total cholesterol, triglycerides, HDL-Cholesterol, GGT, aspartate aminotransferase (AST), and alanine aminotransferase (ALT). IR was calculated using the homeostasis model assessment (HOMA-IR). Serum GGT and ALT, but not AST, were positively correlated with HOMA-IR in boys (r=0.222 for GGT; P<0.05, r=0.188 for ALT; P<0.05) and girls (r=0.292 for GGT; P<0.05, r=0.258 for ALT; P<0.05). In multiple regression analysis for HOMA-IR as dependent variable, GGT (β=0.068; P=0.053 in boys, β=0.145; P=0.002 in girls) and ALT (β=0.074; P=0.034 in boys, β=0.130; P=0.005 in girls) emerged as determinants of HOMA-IR after adjusting age, BMI, tanner stage, and triglycerides. Serum GGT level is a strong marker of IR in obese Korean children.
Reference Key
lee2013internationalelevated Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Seon Yeong Lee;Eunju Sung;Yoosoo Chang
Journal zhonghua wei zhong bing ji jiu yi xue
Year 2013
DOI
10.1155/2013/578693
URL
http://dx.doi.org/10.1155/2013/578693
Keywords
clinical endocrinology diseases of the endocrine glands

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.