dexamethasone therapy for bacterial meningitis: better never than late?

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ID: 242615
1994
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Abstract
A multicentre randomized controlled trial was conducted in children with bacterial meningitis using dexamethasone or placebo for four days within 24 h of starting antibiotics. Primary outcomes were hearing loss and neurological abnormalities at 12 months after meningitis. The dexamethasone (n=50) and placebo (n=51) groups were similar in age, severity of illness and etiological agent. Hearing loss occurred in 10% and 11% of the dexamethasone and placebo groups and neurological deficits occurred in 20% and 18% of patients, respectively. Duodenal perforation occurred in one dexamethasone-treated child. In conclusion, there was no significant benefit in those receiving dexamethasone. The lack of benefit may have been due to the delay in administration of dexamethasone (median delay of 11 h after antibiotics). Therefore, if dexamethasone is used for meningitis it should be given immediately with the antibiotic.
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king1994canadiandexamethasone Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Susan M King;Barbara Law;Joanne M Langley;Helen Heurter;Diane Bremner;Elaine E Wang;Ronald Gold
Journal computer science
Year 1994
DOI
10.1155/1994/257198
URL
http://dx.doi.org/10.1155/1994/257198
Keywords
Infectious and parasitic diseases

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