using gene expression to annotate cardiovascular gwas loci

Clicks: 218
ID: 242404
2018
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Abstract
Genetic variants at hundreds of loci associated with cardiovascular phenotypes have been identified by genome wide association studies. Most of these variants are located in intronic or intergenic regions rendering the functional and mechanistic follow up difficult. These non-protein-coding regions harbor regulatory sequences. Thus the study of genetic variants associated with transcription—so called expression quantitative trait loci—has emerged as a promising approach to identify regulatory sequence variants. The genes and pathways they control constitute candidate causal drivers at cardiovascular risk loci. This review provides an overview of the expression quantitative trait loci resources available for cardiovascular genetics research and the most commonly used approaches for candidate gene identification.
Reference Key
heinig2018frontiersusing Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Matthias Heinig;Matthias Heinig
Journal substance abuse treatment, prevention, and policy
Year 2018
DOI
10.3389/fcvm.2018.00059
URL
https://www.frontiersin.org/article/10.3389/fcvm.2018.00059/full
Keywords
genome wide association study gwas

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