Pathogenicity of fowl adenovirus serotype 4 (FAdV-4) in chickens.

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ID: 24240
2019
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Ranked #18 of 61 articles by views in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

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Abstract
Hepatitis-hydropericardium syndrome (HHS) is an acute infectious disease caused by fowl adenovirus serotype 4 (FAdV-4), which mainly infects broilers aged 3-5 weeks. In March 2018, a pathogenic disease, which was characterized by symptoms similar to HHS, broke out in 10-day-old broiler flocks in Shandong province. In this study, a strain of FAdV-4 (SDSG) was isolated from naturally infected broilers. To assess its pathogenicity, 10-day-old and 20-day-old specific pathogen-free (SPF) chickens were inoculated separately with the FAdV-4 virus fluid via oral and intramuscular injection routes. The results show that typical hydropericardium and hepatitis were observed in experimental chickens. The titer levels of the virus antibody and the levels of inflammatory cytokines were upregulated, which may be caused by the infection and innate immune response. The detection of viral load showed that the presence of virus was detected in multiple organs, in which the liver contained the highest concentration of viral DNA, and the virus content in the intramuscular injection group was higher than that of the oral injection group. In summary, these findings increase our understanding of the pathogenicity of FAdV-4 (SDSG) in chickens. The established model will be valuable for anti-viral drug testing and vaccine evaluation, which can prevent and reduce the spread of HHS in the poultry industry.
Reference Key
sun2019pathogenicityinfection Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sun, Jie;Zhang, Yuanyuan;Gao, Shuo;Yang, Jing;Tang, Yi;Diao, Youxiang;
Journal Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Year 2019
DOI
S1567-1348(19)30244-8
URL
Keywords Keywords not found

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