tumour lysis syndrome and partial remission occurring after administration of a test dose of obinutuzumab

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ID: 242341
2017
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Abstract
Chronic lymphocytic leukaemia (CLL) is one of the most common haematological malignancies worldwide, with an increasing prevalence in the elderly population. Obinutuzumab is a type II anti-CD20 monoclonal antibody which showed superiority over rituximab in combination chemotherapy with chlorambucil for the treatment of CLL in the CLL11 trial (NCT01010061) and is becoming part of standard first line treatment for CLL in the elderly based on its potent efficacy and benign safety profile. We report the case of a chemotherapy naive patient who develop tumour lysis syndrome despite appropriate prophylaxis, and had partial remission of her disease after receiving only the initial test dose of obinutuzumab.
Reference Key
mustafa2017europeantumour Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Mohamad Jaffer Abdalkhalig Mustafa;Mohamed Bakri Mohamed;Amjad Hayat
Journal indian journal of dental research
Year 2017
DOI
10.12890/2016_000516
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